He was involved in the development of methodological guidance related to dynamic simulation modelling, Multi-Criteria Decision Making, constrained optimisation and early HTA. In his research, he takes a data-driven and systems approach to medical (technology) and innovation, particularly around genomics enabled precision oncology. He is the chair of the Rotterdam Global Health Initiative and the chair of ISPOR’s Health Sciences Policy Council. He is a non-executive board member in healthcare institutes and actively promotes research in global and planetary health.